After their breakthrough study went viral in The Times of Israel, Dr. Ariel Ionescu and Dr. Amir Dori join us, alongside Dr. Merit Cudkowicz, to explain what the headlines got right and what still needs caution. Their research suggests ALS may begin at the muscle to nerve connection, where a missing molecule allows toxic protein buildup, and restoring it in lab models stopped decline and supported nerve repair. We talk about what this could mean for families living with ALS, what still stands between this science and human trials, and why real hope is built carefully, without getting ahead of the data.